 |
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
Wong DJ, Liu H, Ridky TW, Cassarino D, Segal E, Chang HY. Module map of stem cell genes guides creation of epithelial cancer stem cells Cell Stem Cell 2008 Apr 10;2(4):333-44.
Rinn JL, Wang JK, Liu H, Montgomery K, van de Rijn M, Chang HY. A systems biology approach to anatomic diversity of skin. J Invest Dermatol. 2008 Apr;128(4):776-82.
Michishita E, McCord RA, Berber E, Kioi M, Padilla-Nash H, Damian M, Cheung P, Kusumoto R, Kawahara TL, Barrett JC, Chang HY, Bohr VA, Ried T, Gozani O, Chua KF. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 2008 Mar 12; [Epub ahead of print]
Adler AS, Kawahara TL, Segal E, Chang HY. Reversal of aging by NFkappaB blockade. Cell Cycle. 2008 Mar;7(5):556-9. Epub 2007 Dec 26.
Sinha S, Adler AS, Field Y, Chang HY, Segal E. Systematic functional characterization of cis-regulatory motifs in human core promoters. Genome Research 2008 Mar;18(3):477-88. Epub 2008 Feb 6.
Rinn JL, Wang JK, Allen N, Brugmann SA, Mikels AJ, Liu H, Ridky TW, Stadler HS, Nusse R, Helms JA, Chang HY. A dermal HOX transcriptional program regulates site-specific epidermal fate. Genes & Development 2008 Feb 1;22(3):303-7.
Adler AS, Littlepage LE, Lin M, Kawahara TL, Wong DJ, Werb Z, Chang HY. CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression. Cancer Research 2008 Jan 15;68(2):506-15.
Wong DJ, Nuyten DS, Regev A, Lin M, Adler AS, Segal E, van de Vijver MJ, Chang HY. Revealing targeted therapy for human cancer by gene module maps. Cancer Research 2008 Jan 15;68(2):369-78.
2007
Adler AS, Sinha S, Kawahara TLA, Zhang JY, Segal E, Chang HY. |
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pubmed | Genes Dev | Web Supplement |
| Cover | News |
Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y.
A histone H3 lysine 27 demethylase regulates animal posterior development.
Nature 2007 Oct 11;449(7163):689-94.
| Pubmed | Nature |
Chang HY, Cotsarelis G.
Turning skin into embryonic stem cells.
Nature Medicine 2007 Jul;13(7):783-4.
| Pubmed | Nature Medicine |
Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E, Chang HY.
Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs.
Cell 2007 Jun 29;129(7):1311-23.
| Pubmed | Cell | Web Supplement |
Liu H, Adler AS, Segal E, Chang HY.
A Transcriptional Program Mediating Entry into Cellular Quiescence.
PLoS Genetics 2007 Jun 8;3(6):e91
| Pubmed | PLoS Genet. | Web Supplement |
O'geen H, Squazzo SL, Iyengar S, Blahnik K, Rinn JL, Chang HY, Green R, Farnham PJ.
Genome-Wide Analysis of KAP1 Binding Suggests Autoregulation of KRAB-ZNFs.
PLoS Genetics 2007 Jun 1;3(6):e89
| Pubmed | PLoS Genet. |
Segal E, Sirlin CB, Ooi C, Adler AS, Gollub J, Chen X, Chan BK, Matcuk GR, Barry CT, Chang HY, Kuo MD.
Decoding global gene expression programs in liver cancer by noninvasive imaging.
Nature Biotechnology 2007 Published online: 21 May 2007; | doi:10.1038/nbt1306
| Pubmed | Nat Biotechnol. | Web Supplement |
Chang HY
Patterning skin pigmentation via dickkopf.
J Invest Dermatology. 2007 May;127(5):994-5.
| Pubmed | J Invest Dermatol. |
2006
Chang HY, Thomson JA, Chen X. Microarray analysis of stem cells and differentiation.
Methods in Enzymology 2006;420:225-54.
| Pubmed | Methods Enzymol. |
Devoss J, Hou Y, Johannes K, Lu W, Liou GI, Rinn J, Chang H, Caspi R, Fong L, Anderson MS.
Spontaneous autoimmunity prevented by thymic expression of a single self-antigen.
J Exp Med. 2006 Nov 20;
| Pubmed | J Exp Med. |
Nuyten DS, Kreike B, Hart AA, Chi JT, Sneddon JB, Wessels LF, Peterse H, Bartelink H, Brown PO, Chang HY, Van de Vijver MJ.
Predicting a local recurrence after breast-conserving therapy by gene expression profiling.
Breast Cancer Research. 2006 Oct 30;8(5):R62
| Pubmed | Breast Cancer Res. |
Huang, W, Chang, HY, Fei, T, Wu, H, Chen, YG.
GSK3beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN.
Oncogene Advance online publication, 9 October 2006; doi:10.1038/sj.onc.1210033.
| Pubmed | Oncogene |
Sneddon, J.B., H.H. Zhen, K. Montgomery, M. vd Rijn, A.D.Tward, R. West, H. Gladstone, H.Y. Chang, G.S. Morganroth, A.E. Oro, P.O. Brown
BMP antagonist Gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation.
Proc. Natl Acad. Sci. USA 2006 103, 14842-14847
| Pubmed | PNAS |
Rinn, JL, Bondre, C, Gladstone, HB, Brown, PO, Chang, HY
Anatomic demarcation by positional variation in fibroblast gene expression programs.
PLoS Genetics 2006 2(7): e119.
| Pubmed | PLoS Genetics |
Ray, S, Atkuri, KR, Deb-Basu, D, Adler, AS, Chang, HY, Herzenberg, LA, Felsher, DW
MYC Can Induce DNA Breaks In vivo and In vitro Independent of Reactive Oxygen Species.
Cancer Research 2006 Jul;66(13):6598-6605.
| Pubmed | Cancer Res |
Adler AS and Chang, HY
From Description to Causality: Mechanisms of Gene Expression Signatures in Cancer.
Cell Cycle 2006 Jun;5(11):1148-1151.
| Pubmed | Cell Cycle |
Adler AS, Lin M, Horlings H, Nuyten DSA, van de Vijver M, Chang, HY.
Genetic regulators of large-scale transcriptional signatures in cancer
Nature Genetics 2006 Apr;38(4):421-430.
| Pubmed | Nature Genetics | Web Supplement |
2005
Wong, DJ and Chang, HY Learning more from microarrays: Lessons from modules and networks.
J Invest Dermatol 2005 Aug; 125(2):175-182.
| Pubmed | JID |
Chang HY, Nuyten DS, Sneddon JB, Hastie T, Tibshirani R, Sorlie T, Dai H, He YD, Van't Veer LJ, Bartelink H, van de Rijn M, Brown PO, van de Vijver MJ.
Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival
Proc Natl Acad Sci USA 2005 Mar 8; 102(10):3738-3743.
| Pubmed | PNAS | Web Supplement |
Before 2005
Chang HY, Sneddon JB, Alizadeh AA, Sood R, West RB, Montgomery K, Chi JT, van de Rijn M, Botstein D, Brown PO.
Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds.
PLoS Biol 2004 Feb; 2(2):E7.
| Pubmed | PLoS Biology | Web Supplement |
Chang, HY, Thomson, JA, Chen, X.
Microarray analysis of stem cells and differentiation.
Handbook of Adult and Fetal Stem Cells. 2004. R. Lanza et al., Eds. (San Diego: Academic Press).
Chi JT, Chang HY, Haraldsen G, Jahnsen FL, Troyanskaya OG, Chang DS, Wang Z, Rockson SG, van de Rijn M, Botstein D, Brown PO.
Endothelial cell diversity revealed by global expression profiling.
Proc Natl Acad Sci U S A 2003 Sep 16; 100(19): 10623-10628.
| Pubmed | PNAS | Web Supplement |
Chi, JT, Chang, HY, Wang, NN, Chang, DS, Dunphy, N, Brown, PO.
Genome-wide view of gene silencing by small interfering RNAs.
Proc Natl Acad Sci USA 2003, 100, 6343-6346. Recommended by Faculty of 1000.
| Pubmed | PNAS |
Chang HY, Chi JT, Dudoit S, Bondre C, van de Rijn M, Botstein D, Brown PO.
Diversity, topographic differentiation, and positional memory in human fibroblasts.
Proc Natl Acad Sci USA 2002 Oct 1; 99(20): 12877-12882.
| Pubmed | PNAS | Web Supplement |
Chang, HY and Yang X.
Proteases for cell suicide: regulation and functions of caspases. Microbiol Molec Biol Review 2000, 64, 821-846.
Chang, HY, Yang, X, Baltimore, D.
Dissecting Fas signaling with an altered specificity death-domain mutant: Requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation.
Proc Natl Acad Sci USA 1999, 96, 1252-1256.
Chang, HY, H Nishitoh, X Yang, H Ichijo, and D Baltimore.
Activation of Apoptosis Signal-regulating Kinase 1 (ASK1) by the adapter protein Daxx.
Science 1998, 281, 1860-1863.
Yang, X., H.Y. Chang, and D. Baltimore.
Essential role of CED-4 oligomerization in CED-3 activation and apoptosis.
Science 1998, 281, 1355-1357.
Yang, X., H.Y. Chang, and D. Baltimore
Autoproteolytic activation of pro-caspases by oligomerization.
Molecular Cell 1998, 1, 319-325.
Yang, X., R. Khosravi-Far, H.Y. Chang, and D. Baltimore.
Daxx, a novel Fas-binding protein that activates JNK and apoptosis.
Cell 1997, 89, 1067-1076.
Chang, H.Y., K. Takei, A.M. Sydor, T. Born, F. Rusnak, and D.G. Jay.
Asymmetric retraction of growth cone filopodia following focal inactivation of calcineurin.
Nature 1995, 376, 686-690.
DiComo, C.J., H.Y. Chang, and K.T. Arndt. (1995)
Activation of CLN1 and CLN2 G1 cyclin expression by BCK2.
Mol Cell Biol 1995, 15, 1835-1846.
Zydowsky, L.D., F.A. Etzkorn, H.Y. Chang, S.B. Ferguson, L.A. Stoltz, S.I. Ho, and C.T. Walsh.
Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition.
Protein Science 1992, 1, 1092-1099.
Swanson, S.K.-H., T. Born, L.D. Zydowsky, H. Cho, H.Y. Chang, C.T. Walsh, and F. Rusnak. (1992)
Cyclosporin-mediated inhibition of bovine calcineurin by cyclophilin A and B.
Proc Natl Acad Sci USA 1992, 89, 3741-3745.