|     2006   |     2005  |    Before 2005  |


Chang HY, Thomson JA, Chen X.
Microarray analysis of stem cells and differentiation.
Methods in Enzymology 2006;420:225-54.
Pubmed Methods Enzymol.   PDF

Devoss J, Hou Y, Johannes K, Lu W, Liou GI, Rinn J, Chang H, Caspi R, Fong L, Anderson MS.
Spontaneous autoimmunity prevented by thymic expression of a single self-antigen.
J Exp Med. 2006 Nov 20;
Pubmed J Exp Med.   PDF

Nuyten DS, Kreike B, Hart AA, Chi JT, Sneddon JB, Wessels LF, Peterse H, Bartelink H, Brown PO, Chang HY, Van de Vijver MJ.
Predicting a local recurrence after breast-conserving therapy by gene expression profiling.
Breast Cancer Research. 2006 Oct 30;8(5):R62
Pubmed Breast Cancer Res.   PDF

Huang, W, Chang, HY, Fei, T, Wu, H, Chen, YG.
GSK3beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN.
Oncogene Advance online publication, 9 October 2006; doi:10.1038/sj.onc.1210033.
Pubmed Oncogene   PDF

Sneddon, J.B., H.H. Zhen, K. Montgomery, M. vd Rijn, A.D.Tward, R. West, H. Gladstone, H.Y. Chang, G.S. Morganroth, A.E. Oro, P.O. Brown
BMP antagonist Gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation.
Proc. Natl Acad. Sci. USA 2006 103, 14842-14847
Pubmed PNAS   PDF

Rinn, JL, Bondre, C, Gladstone, HB, Brown, PO, Chang, HY
Anatomic demarcation by positional variation in fibroblast gene expression programs.
PLoS Genetics 2006 2(7): e119.
Pubmed PLoS Genetics   PDF

Ray, S, Atkuri, KR, Deb-Basu, D, Adler, AS, Chang, HY, Herzenberg, LA, Felsher, DW
MYC Can Induce DNA Breaks In vivo and In vitro Independent of Reactive Oxygen Species.
Cancer Research 2006 Jul;66(13):6598-6605.
Pubmed Cancer Res   PDF

Adler AS and Chang, HY
From Description to Causality: Mechanisms of Gene Expression Signatures in Cancer.
Cell Cycle 2006 Jun;5(11):1148-1151.
Pubmed Cell Cycle   PDF

Adler AS, Lin M, Horlings H, Nuyten DSA, van de Vijver M, Chang, HY.
Genetic regulators of large-scale transcriptional signatures in cancer
Nature Genetics 2006 Apr;38(4):421-430.
Pubmed Nature Genetics Web Supplement PDF 


Wong, DJ and Chang, HY
Learning more from microarrays: Lessons from modules and networks.
J Invest Dermatol 2005 Aug; 125(2):175-182.
Pubmed JID   PDF

Chang HY, Nuyten DS, Sneddon JB, Hastie T, Tibshirani R, Sorlie T, Dai H, He YD, Van't Veer LJ, Bartelink H, van de Rijn M, Brown PO, van de Vijver MJ.
Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival
Proc Natl Acad Sci USA 2005 Mar 8; 102(10):3738-3743.
Pubmed PNAS Web Supplement PDF

Before 2005

Chang HY, Sneddon JB, Alizadeh AA, Sood R, West RB, Montgomery K, Chi JT, van de Rijn M, Botstein D, Brown PO.
Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds.
PLoS Biol 2004 Feb; 2(2):E7.
Pubmed PLoS Biology Web Supplement PDF

Chang, HY, Thomson, JA, Chen, X.
Microarray analysis of stem cells and differentiation.
Handbook of Adult and Fetal Stem Cells. 2004. R. Lanza et al., Eds. (San Diego: Academic Press).

Chi JT, Chang HY, Haraldsen G, Jahnsen FL, Troyanskaya OG, Chang DS, Wang Z, Rockson SG, van de Rijn M, Botstein D, Brown PO.
Endothelial cell diversity revealed by global expression profiling.
Proc Natl Acad Sci U S A 2003 Sep 16; 100(19): 10623-10628.
Pubmed PNAS Web Supplement PDF

Chi, JT, Chang, HY, Wang, NN, Chang, DS, Dunphy, N, Brown, PO.
Genome-wide view of gene silencing by small interfering RNAs.
Proc Natl Acad Sci USA 2003, 100, 6343-6346. Recommended by Faculty of 1000.
Pubmed PNAS   PDF

Chang HY, Chi JT, Dudoit S, Bondre C, van de Rijn M, Botstein D, Brown PO.
Diversity, topographic differentiation, and positional memory in human fibroblasts.
Proc Natl Acad Sci USA 2002 Oct 1; 99(20): 12877-12882.
Pubmed PNAS Web Supplement PDF

Chang, HY and Yang X.
Proteases for cell suicide: regulation and functions of caspases. Microbiol Molec Biol Review 2000, 64, 821-846.

Chang, HY, Yang, X, Baltimore, D.
Dissecting Fas signaling with an altered specificity death-domain mutant: Requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation.
Proc Natl Acad Sci USA 1999, 96, 1252-1256.

Chang, HY, H Nishitoh, X Yang, H Ichijo, and D Baltimore.
Activation of Apoptosis Signal-regulating Kinase 1 (ASK1) by the adapter protein Daxx.
Science 1998, 281, 1860-1863.

Yang, X., H.Y. Chang, and D. Baltimore.
Essential role of CED-4 oligomerization in CED-3 activation and apoptosis.
Science 1998, 281, 1355-1357.

Yang, X., H.Y. Chang, and D. Baltimore
Autoproteolytic activation of pro-caspases by oligomerization.
Molecular Cell 1998, 1, 319-325.

Yang, X., R. Khosravi-Far, H.Y. Chang, and D. Baltimore.
Daxx, a novel Fas-binding protein that activates JNK and apoptosis.
Cell 1997, 89, 1067-1076.

Chang, H.Y., K. Takei, A.M. Sydor, T. Born, F. Rusnak, and D.G. Jay.
Asymmetric retraction of growth cone filopodia following focal inactivation of calcineurin.
Nature 1995, 376, 686-690.

DiComo, C.J., H.Y. Chang, and K.T. Arndt. (1995)
Activation of CLN1 and CLN2 G1 cyclin expression by BCK2.
Mol Cell Biol 1995, 15, 1835-1846.

Zydowsky, L.D., F.A. Etzkorn, H.Y. Chang, S.B. Ferguson, L.A. Stoltz, S.I. Ho, and C.T. Walsh.
Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition.
Protein Science 1992, 1, 1092-1099.

Swanson, S.K.-H., T. Born, L.D. Zydowsky, H. Cho, H.Y. Chang, C.T. Walsh, and F. Rusnak. (1992)
Cyclosporin-mediated inhibition of bovine calcineurin by cyclophilin A and B.
Proc Natl Acad Sci USA 1992, 89, 3741-3745.

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