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Chang HY.
Anatomic Demarcation of Cells: Genes to Patterns
Science 2009 Nov 27;326(5957):1206-7.
Pubmed Science   PDF

Sargent JL, Milano A, Bhattacharyya S, Varga J, Connolly MK, Chang HY, Whitfield ML.
A TGFbeta-Responsive Gene Signature Is Associated with a Subset of Diffuse Scleroderma with Increased Disease Severity.
J Invest Dermatol. 2009 Oct 8. [Epub ahead of print]
Pubmed J Invest Dermatol   PDF

Wong DJ and Chang HY.
Skin Tissue Engineering.
StemBook 2009
  StemBook   PDF

Chan KS, Espinosa I, Chao M, Wong DJ, Ailles L, Diehn M, Gill H, Presti J Jr, Chang HY, van de Rijn M, Shortliffe L, Weissman IL.
Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells.
Proc. Natl Acad. Sci. USA 2009 Aug 4. [Epub ahead of print]
Pubmed PNAS   PDF

Mace KA, Restivo TE, Rinn JL, Paquet AC, Chang HY, Young DM, Boudreau NJ.
HOXA3 modulates injury-induced mobilization and recruitment of bone marrow-derived cells.
Stem Cells. 2009 Jul;27(7):1654-65
Pubmed Stem Cells   PDF

Chang HY, Cuvier O, Dekker J.
Gene dates, parties and galas. Symposium on Chromatin Dynamics and Higher Order Organization.
EMBO Rep 2009 Jun 12. [Epub ahead of print]
Pubmed EMBO Rep   PDF

Chan DA, Kawahara TL, Sutphin PD, Chang HY, Chi JT, Giaccia AJ.
Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.
Cancer Cell 2009 Jun 2;15(6):527-38
Pubmed Cancer Cell   PDF

Reuter JA, Ortiz-Urda S, Kretz M, Garcia J, Scholl FA, Pasmooij AM, Cassarino D, Chang HY, Khavari PA.
Modeling inducible human tissue neoplasia identifies an extracellular matrix interaction network involved in cancer progression.
Cancer Cell 2009 Jun 2;15(6):477-88
Pubmed Cancer Cell   PDF

Wang KC, Helms JA, Chang HY.
Regeneration, repair and remembering identity: the three Rs of Hox gene expression.
Trends in Cell Biology 2009 May 8. [Epub ahead of print]
Pubmed Trends Cell Biol   PDF

Rando OJ, Chang HY.
Genome-wide views of chromatin structure.
Annu Rev Biochem. 2009 Mar 24. [Epub ahead of print]
Pubmed Annu Rev Biochem   PDF

Chung L, Fiorentino DF, Benbarak MJ, Adler AS, Mariano MM, Paniagua RT, Milano A, Connolly MK, Ratiner BD, Wiskocil RL, Whitfield ML, Chang HY, Robinson WH.
Molecular framework for response to imatinib mesylate in systemic sclerosis.
Arthritis Rheum. 2009 Feb;60(2):584-91
Pubmed Arthritis Rheum   PDF

Somervaille TC, Matheny CJ, Spencer GJ, Iwasaki M, Rinn JL, Witten DM, Chang HY, Shurtleff SA, Downing JR, Cleary ML.
Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells.
Cell Stem Cell. 2009 Feb 6;4(2):129-40.
Pubmed Cell Stem Cell   PDF

Hung T, Binda O, Champagne KS, Kuo AJ, Johnson K, Chang HY, Simon MD, Kutateladze TG, Gozani O.
ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation.
Mol Cell. 2009 Jan 30;33(2):248-56
Pubmed Mol Cell   PDF

Kawahara TL, Michishita E, Adler AS, Damian M, Berber E, Lin M, McCord RA, Ongaigui KC, Boxer LD, Chang HY, Chua KF.
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.
Cell. 2009 Jan 9;136(1):62-74.
Pubmed Cell Web Supplement PDF


Sääf AM, Tengvall-Linder M, Chang HY, Adler AS, Wahlgren CF, Scheynius A, Nordenskjöld M, Bradley M.
Global expression profiling in atopic eczema reveals reciprocal expression of inflammatory and lipid genes.
PLoS ONE.2008;3(12):e4017. Epub 2008 Dec 24.
Pubmed PLoS ONE   PDF

Wong DJ, Segal E, Chang HY.
Stemness, cancer and cancer stem cells.
Cell Cycle. 2008 Dec 2;7(23).
Pubmed Cell Cycle   PDF

Nuyten DS, Hastie T, Chi JT, Chang HY, van de Vijver MJ.
Combining biological gene expression signatures in predicting outcome in breast cancer: An alternative to supervised classification.
Eur J Cancer. 2008 Oct;44(15):2319-29. Epub 2008 Aug 18.
Pubmed Eur J Cancer   PDF

Gardner JM, Devoss JJ, Friedman RS, Wong DJ, Tan YX, Zhou X, Johannes KP, Su MA, Chang HY, Krummel MF, Anderson MS.
Deletional tolerance mediated by extrathymic Aire-expressing cells.
Science. 2008 Aug 8;321(5890):843-7.
Pubmed Science Perspectives PDF

Sen GL, Webster DE, Barragan DI, Chang HY, Khavari PA.
Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3.
Genes & Development. 2008 Jul 15;22(14):1865-70.
Pubmed Genes Dev   PDF

Su MA, Giang K, Zumer K, Jiang H, Oven I, Rinn JL, Devoss JJ, Johannes KP, Lu W, Gardner J, Chang A, Bubulya P, Chang HY, Peterlin BM, Anderson MS.
Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire.
J Clin Invest. 2008 May;118(5):1712-26.
Pubmed JCI Cover PDF

Wong DJ, Liu H, Ridky TW, Cassarino D, Segal E, Chang HY.
Module map of stem cell genes guides creation of epithelial cancer stem cells
Cell Stem Cell 2008 Apr 10;2(4):333-44.
Pubmed Cell Stem Cell Web Supplement PDF
Cover Commentary    

Rinn JL, Wang JK, Liu H, Montgomery K, van de Rijn M, Chang HY.
A systems biology approach to anatomic diversity of skin.
J Invest Dermatol. 2008 Apr;128(4):776-82.
Pubmed JID   PDF

Michishita E, McCord RA, Berber E, Kioi M, Padilla-Nash H, Damian M, Cheung P, Kusumoto R, Kawahara TL, Barrett JC, Chang HY, Bohr VA, Ried T, Gozani O, Chua KF.
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.
Nature 2008 Mar 12; [Epub ahead of print]
Pubmed Nature   PDF

Adler AS, Kawahara TL, Segal E, Chang HY.
Reversal of aging by NFkappaB blockade.
Cell Cycle. 2008 Mar;7(5):556-9. Epub 2007 Dec 26.
Pubmed Cell Cycle   PDF

Sinha S, Adler AS, Field Y, Chang HY, Segal E.
Systematic functional characterization of cis-regulatory motifs in human core promoters.
Genome Research 2008 Mar;18(3):477-88. Epub 2008 Feb 6.
Pubmed Genome Res Web Supplement PDF

Rinn JL, Wang JK, Allen N, Brugmann SA, Mikels AJ, Liu H, Ridky TW, Stadler HS, Nusse R, Helms JA, Chang HY.
A dermal HOX transcriptional program regulates site-specific epidermal fate.
Genes & Development 2008 Feb 1;22(3):303-7.
Pubmed Genes Dev Web Supplement PDF

Adler AS, Littlepage LE, Lin M, Kawahara TL, Wong DJ, Werb Z, Chang HY.
CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression.
Cancer Research 2008 Jan 15;68(2):506-15.
Pubmed Cancer Res Web Supplement PDF

Wong DJ, Nuyten DS, Regev A, Lin M, Adler AS, Segal E, van de Vijver MJ, Chang HY.
Revealing targeted therapy for human cancer by gene module maps.
Cancer Research 2008 Jan 15;68(2):369-78.
Pubmed Cancer Res Web Supplement PDF


Adler AS, Sinha S, Kawahara TLA, Zhang JY, Segal E, Chang HY.
Motif module map reveals enforcement of aging by continual NF-kB activity.
Genes & Development 2007 Dec 15;21(24):3244-57.
Pubmed Genes Dev Web Supplement PDF
Cover News    

Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y.
A histone H3 lysine 27 demethylase regulates animal posterior development.
Nature 2007 Oct 11;449(7163):689-94.
Pubmed Nature   PDF

Chang HY, Cotsarelis G.
Turning skin into embryonic stem cells.
Nature Medicine 2007 Jul;13(7):783-4.
Pubmed Nature Medicine   PDF

Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E, Chang HY.
Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs.
Cell 2007 Jun 29;129(7):1311-23.
Pubmed Cell Web Supplement PDF

Liu H, Adler AS, Segal E, Chang HY.
A Transcriptional Program Mediating Entry into Cellular Quiescence.
PLoS Genetics 2007 Jun 8;3(6):e91
Pubmed PLoS Genet. Web Supplement PDF

O'geen H, Squazzo SL, Iyengar S, Blahnik K, Rinn JL, Chang HY, Green R, Farnham PJ.
Genome-Wide Analysis of KAP1 Binding Suggests Autoregulation of KRAB-ZNFs.
PLoS Genetics 2007 Jun 1;3(6):e89
Pubmed PLoS Genet.   PDF

Segal E, Sirlin CB, Ooi C, Adler AS, Gollub J, Chen X, Chan BK, Matcuk GR, Barry CT, Chang HY, Kuo MD.
Decoding global gene expression programs in liver cancer by noninvasive imaging.
Nature Biotechnology 2007 Published online: 21 May 2007; | doi:10.1038/nbt1306
Pubmed Nat Biotechnol. Web Supplement PDF

Chang HY
Patterning skin pigmentation via dickkopf.
J Invest Dermatology. 2007 May;127(5):994-5.
Pubmed J Invest Dermatol.   PDF

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