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| Curriculum Vitae |
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| Howard Y. Chang |
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Personal Data |
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| Born: 1972 in Taipei, Taiwan |
Citizenship: U.S.A |
| Address: 2155c CCSR |
Phone: (650) 736-0306 |
| 269 Campus Drive |
Email: howchang@stanford.edu |
| Stanford, CA 94305-5168 |
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Employment |
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| 2004-current |
Assistant Professor of Dermatology
Faculty member, Cancer Biology Ph.D. program.
Stanford University School of Medicine, Stanford, CA. |
| 2005-current |
Member, Stanford Comprehensive Cancer Center |
Education and Training
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1990-1994 |
A.B. in Biochemical Sciences, Summa cum laude
Harvard University, Cambridge, MA.
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1996-1998 |
Ph.D. in Biology. Massachusetts Institute of Technology, Cambridge, MA. Advisor: Prof. David Baltimore.
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1994-2000 |
M.D. Harvard Medical School, Boston, MA. Harvard-MIT Division of Health Science and Technology.
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2000-2001 |
Internship in Internal Medicine. Santa Clara Valley Medical Center, San Jose, CA.
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2001-2004 |
Residency in Dermatology. Stanford University School of Medicine, Stanford, CA.
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2000-2004 |
Postdoctoral research fellowship. Stanford University School of Medicine, Stanford, CA. Advisor: Prof. Patrick O. Brown.
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| Licensure |
Physician and Surgeon, State of California
Diplomate, American Board of Dermatology.
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Honors |
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Honorary American Junior Academy of Science member |
1990 |
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National Forensics League: Degree of Special Distinction |
1990 |
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Detur Prize: top 60 Freshman scholar at Harvard College |
1991 |
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Cold Spring Harbor Laboratory Undergraduate Research Program |
1992, 1993 |
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John Harvard Scholarship | 1992-1994 |
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Phi Beta Kappa: one of top 24 students at Harvard College, class of '94 |
1993 |
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National Institute of Health Medical Scientist Training Program |
1994-2000 |
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Ivan Cottrell Research Fellowship, MIT Department of Biology |
1995 |
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Soma Weiss Prize: awarded for excellence in research at Harvard Medical School |
2000 |
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Leon Reznick Memorial Prize: "for outstanding performance in research and scholarly activities."
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2000 |
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Society of Investigative Dermatology, Resident Retreat for Future Physician-Scientists.
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2002 |
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American Academy of Dermatology Young Investigator Award
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2003 |
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NIH/NIAMS T32 National Research Service Award |
2003-2004 |
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Dermatology Foundation Physician-Scientist Career Development Award |
2004 |
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NIH/NIAMS Clinical Scientist Career Development Award |
2004-2009 |
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Damon Runyon Scholar Award |
2006-2009 |
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Publications |
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1. Chang, H.Y. (1992) Scientific whaling. Harvard Science Review 5, 17-21. |
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2. Swanson, S.K.-H., T. Born, L.D. Zydowsky, H. Cho, H.Y. Chang, C.T. Walsh, and F. Rusnak.(1992) Cyclosporin-mediated inhibition of bovine calcineurin by cyclophilin A and B. Proc. Natl. Acad. Sci. USA 89, 3741-3745. |
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3 Zydowsky, L.D., F.A. Etzkorn, H.Y. Chang, S.B. Ferguson, L.A. Stoltz, S.I. Ho, and C.T. Walsh. (1992) Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition. Protein Science 1, 1092-1099. |
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4. DiComo, C.J., H.Y. Chang, and K.T. Arndt. (1995) Activation of CLN1 and CLN2 G1 cyclin expression by BCK2. Mol. Cell. Biol. 15, 1835-1846. |
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5. Chang, H.Y., K. Takei, A.M. Sydor, T. Born, F. Rusnak, and D.G. Jay (1995) Asymmetric retraction of growth cone filopodia following focal inactivation of calcineurin. Nature 376, 686-690. |
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6. Yang, X. ‡, R. Khosravi-Far‡, H.Y. Chang‡, and D. Baltimore (1997) Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell 89, 1067-1076. ‡these authors contributed equally. |
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7. Yang, X., H.Y. Chang, and D. Baltimore (1998) Autoproteolytic activation of pro-caspases by oligomerization. Molecular Cell 1, 319-325. |
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8. Yang, X., H.Y. Chang, and D. Baltimore (1998) Essential role of CED-4 oligomerization in CED-3 activation and apoptosis. Science 281, 1355-1357. |
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9. Chang, H.Y., H. Nishitoh, X. Yang, H. Ichijo, and D. Baltimore (1998) Activation of Apoptosis Signal-regulating Kinase 1 (ASK1) by the adapter protein Daxx. Science 281, 1860-1863. |
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10. Chang, H.Y. (1998) Molecular studies of Fas signaling and programmed cell death. Massachusetts Institute of Technology, Doctoral Thesis. |
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11. Chang, H.Y., X. Yang, D. Baltimore (1999) Dissecting Fas signaling with an altered specificity death-domain mutant: Requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation. Proc. Natl. Acad. Sci. USA 96,1252-1256. |
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12. Chang, H.Y. and X. Yang. (2000) Proteases for cell suicide: regulation and functions of caspases. Microbiol. Molec. Biol. Review 64, 821-846. |
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13. Chang, H.Y., J.-T. Chi, S. Dudoit, C. Bondre, M.v.d. Rijn, D. Botstein, P. O. Brown. (2002) Diversity, topographic differentiation, and positional memory in human fibroblasts. Proc. Natl Acad. Sci. USA 99, 12877-12882. http://genome-www.stanford.edu/fibroblast/ |
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14. Chi, J-T. ‡, H.Y. Chang‡, N.N. Wang, D.S. Chang, N. Dunphy, P.O. Brown (2003) Genome-wide view of gene silencing by small interfering RNAs. Proc. Natl Acad. Sci. USA 100, 6343-6346. ‡these authors contributed equally. Recommended by Faculty of 1000. |
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15. Chi, J.T., H.Y. Chang, G. Haraldsen, O. Troyanskaya, D.S. Chang, S.G. Rockson, D. Botstein, P.O. Brown (2003) Endothelial cell diversity revealed by global gene expression profiling. Proc. Natl Acad. Sci. USA, 100, 10623-10628. http://microarray-pubs.stanford.edu/endothelial/ |
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16. Chang, H.Y., K. Wong, M. Bosenberg, P.H. McKee, H.A. Haynes. (2003) Myelogenous leukemia cutis resembling stasis dermatitis. J. Amer. Acad. Dermatology, 49, 128-129. |
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17. Chang, H.Y. , T. W. Ridky, A. B. Kimball, E. Hughes, and A. E. Oro. (2003) Eruptive xanthomas and olanzapine use. Archives of Dermatology,139,, 1045-1048. |
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18. Chang, H.Y., Z. Cooper, S. M. Swetter, M. P. Marinkovich. (2004) Kinetics and specificity of Fas ligand induction in toxic epidermal necrolysis. Archives of Dermatology,140, 242-244. |
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19. Chang, H.Y. (2004) Young Investigator Award 2003: Topographic differentiation of fibroblasts. J. Amer. Acad. Dermatology, e1. |
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20. Chang, H.Y., J.A. Thomson, Chen, X. (2004) Microarray analysis of stem cells and differentiation. In: Handbook of Adult and Fetal Stem Cells. R. Lanza et al., Eds. (San Diego: Academic Press).
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21. Chang, H.Y., J.B. Sneddon, A. Alizadeh, R. Sood, R. West, J.T. Chi, M.v.d. Rijn, D. Botstein, P.O. Brown (2004) Gene expression signature of fibroblast serum response predicts human cancer progression: Similarities between tumors and wounds. PLoS Biology, 2, 206-214. http://microarray-pubs.stanford.edu/wound/. Featured on National Public Radio "Science Friday". BBC News, Genome News Network, Lancet Oncology and Genome Biology. |
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22. Chang, H.Y., D.S.A. Nuyten, J.B. Sneddon, T. Hastie, R. Tibshirani, T. Sorlie, H. Dai, Y. He, L.v.t. Veer, H. Bartelink, M.v.d. Rijn, P.O. Brown, M.J.v.d. Vijver. (2005) Robustness, scalability, and integration of a wound response gene expression signature in predicting breast cancer survival. Proc. Natl Acad. Sci. USA,102, 3738-3743.
Cover article. Editorial in PNAS 102, 3531-2. Featured in JAMA, Nature Review Cancer, Science News. |
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23. Chang, H.Y., Wang, N., Chi, J.-T. (2005) High throughput RNA interference. In: RNA interference Technology: From Basic Science to Drug Development. K. Appasani, Ed. (Cambridge, UK: Cambridge University Press). |
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24. Chang, H.Y. (2005) Programmed cell death in cancer pathogenesis and treatment. In: Cancer Chemotherapy and Chemoprevention, J. Han, ed. (Beijing, PRC: Scientific Publisher). |
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25. Chang, H.Y., J.A. Thomson, Chen, X. (2005) Microarray analysis of stem cells and differentiation. In: Essentials of Stem Cell Biology. R. Lanza et al., Eds. (San Diego: Academic Press). |
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26. Tang, J., H.Y. Chang, X. Yang. (2005) The death domain associated protein modulates activity of the transcriptional cofactor Skip/NcoA62. FEBS Letters. 579, 2883-90. |
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27. Wong, D.J.., H.Y. Chang (2005) Learning more from microarrays: Insights from modules and networks. J. Investigative Dermatology, 125, 175-182.
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28. Adler, A.S., M. Lin, H. Horlings, D.S.A. Nuyten, MJ. vd Vijver, H.Y. Chang (2006) Genetic regulators of large-scale transcriptional signatures in cancer. Nature Genetics, 38, 421-430.
Featured in Nat Review Genet, 2006, 7, 244-245; Cancer Cell 2006, 9, 245-347; Nat Biotech 2006, 24, 524-6.
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29. Adler, A.S., H.Y. Chang (2006)From description to causality: Mechanisms of gene expression signatures in cancer. Cell Cycle, 5, 1148-1151.
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30. Ray, S., K.R. Atkuri, D. Deb-Basu, A.S. Adler, H.Y. Chang L.A. Herzenberg and D.W. Felsher (2006) MYC overexpression can induce DNA breaks in vivo and in vitro through mechanisms independent or dependent upon ROS production.Cancer Research, 66, 6598-6605.
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31. Rinn, J.L., C. Bondre, H. B. Gladstone, P.O. Brown, H.Y. Chang (2006) Anatomic demarcation by positional variation in fibroblast gene expression programs.PLoS Genetics, 2, e119.
Featured in New York Times, NY Daily News, Genome News Network, American Scientist.
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32. Sneddon, J.B., H.H. Zhen, K. Montgomery, M. vd Rijn, A.D.Tward, R. West, H. Gladstone, H.Y. Chang, G.S. Morganroth, A.E. Oro, P.O. Brown (2006) BMP antagonist Gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation.Proc. Natl Acad. Sci. USA,, 103, 14842-14847.
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33. Huang, W., H.Y. Chang, T. Fei, H. Wu, Y-G. Chen (2006) GSK3 mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene, in press.
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34. Chang, HY, J.A. Thomson, X. Chen.(2006) Microarray analysis of stem cells and differentiation. Methods in Enzymology, in press.
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35. Chang, HY, (2006) Patterning skin pigmentation via Dickkopf (Invited commentary). J. Investigative Dermatology, in press.
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36. Huang, W, Chang, HY, Fei, T, Wu, H, Chen, YG. (2006) GSK3beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene, Advance online publication, 9 October 2006; doi:10.1038/sj.onc.1210033.
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37. Nuyten DS, Kreike B, Hart AA, Chi JT, Sneddon JB, Wessels LF, Peterse H, Bartelink H, Brown PO, Chang HY, Van de Vijver MJ. (2006) Predicting a local recurrence after breast-conserving therapy by gene expression profiling. Breast Cancer Res., 2006 Oct 30;8(5):R62
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38. Devoss J, Hou Y, Johannes K, Lu W, Liou GI, Rinn J, Chang H, Caspi R, Fong L, Anderson MS. (2006) Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J Exp Med., 2006 Nov 20;
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Patents |
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1. U.S. Patent 6159731 "Daxx, a novel Fas-binding protein that activates JNK and apoptosis." |
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2. U.S. Patent 6916917 "Chimeric pro-caspases and methods of using same." |
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3. U.S. Provisional Patent 60/452,449 "siRNA microarray and methods for using the same." |
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4. U.S. Provisional Patent 60/452,379 "Methods and compositions for selective RNAi mediated inhibition of gene expression in mammal cells."
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5. U.S. Provisional Patent 11/332,547 “Gene expression signatures for prediction of human cancer progression.”
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