Curriculum Vitae
Howard Y. Chang

Personal Data

Born: 1972 in Taipei, Taiwan Citizenship: U.S.A
Address: 2155c CCSR Phone: (650) 736-0306
269 Campus Drive Email: howchang@stanford.edu
Stanford, CA 94305-5168  


Assistant Professor of Dermatology
Faculty member, Cancer Biology Ph.D. program.
Stanford University School of Medicine, Stanford, CA.
Member, Stanford Comprehensive Cancer Center

Education and Training



A.B. in Biochemical Sciences, Summa cum laude
Harvard University, Cambridge, MA.


Ph.D. in Biology. Massachusetts Institute of Technology, Cambridge, MA. Advisor: Prof. David Baltimore.


M.D. Harvard Medical School, Boston, MA. Harvard-MIT Division of Health Science and Technology.


Internship in Internal Medicine. Santa Clara Valley Medical Center, San Jose, CA.


Residency in Dermatology. Stanford University School of Medicine, Stanford, CA.


Postdoctoral research fellowship. Stanford University School of Medicine, Stanford, CA. Advisor: Prof. Patrick O. Brown.
Physician and Surgeon, State of California
Diplomate, American Board of Dermatology.


  Honorary American Junior Academy of Science member 1990
  National Forensics League: Degree of Special Distinction 1990
  Detur Prize: top 60 Freshman scholar at Harvard College 1991
  Cold Spring Harbor Laboratory Undergraduate Research Program 1992, 1993
  John Harvard Scholarship 1992-1994
  Phi Beta Kappa: one of top 24 students at Harvard College, class of '94 1993
  National Institute of Health Medical Scientist Training Program 1994-2000
  Ivan Cottrell Research Fellowship, MIT Department of Biology 1995
  Soma Weiss Prize: awarded for excellence in research at Harvard Medical School 2000
  Leon Reznick Memorial Prize: "for outstanding performance in research and scholarly activities." 2000
  Society of Investigative Dermatology, Resident Retreat for Future Physician-Scientists. 2002
  American Academy of Dermatology Young Investigator Award 2003
  NIH/NIAMS T32 National Research Service Award 2003-2004
  Dermatology Foundation Physician-Scientist Career Development Award 2004
  NIH/NIAMS Clinical Scientist Career Development Award 2004-2009
  Damon Runyon Scholar Award 2006-2009

1.  Chang, H.Y. (1992) Scientific whaling. Harvard Science Review 5, 17-21.
2.  Swanson, S.K.-H., T. Born, L.D. Zydowsky, H. Cho, H.Y. Chang, C.T. Walsh, and F. Rusnak.(1992) Cyclosporin-mediated inhibition of bovine calcineurin by cyclophilin A and B. Proc. Natl. Acad. Sci. USA 89, 3741-3745.
3  Zydowsky, L.D., F.A. Etzkorn, H.Y. Chang, S.B. Ferguson, L.A. Stoltz, S.I. Ho, and C.T. Walsh. (1992) Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition. Protein Science 1, 1092-1099.
4.  DiComo, C.J., H.Y. Chang, and K.T. Arndt. (1995) Activation of CLN1 and CLN2 G1 cyclin expression by BCK2. Mol. Cell. Biol. 15, 1835-1846.
5.  Chang, H.Y., K. Takei, A.M. Sydor, T. Born, F. Rusnak, and D.G. Jay (1995) Asymmetric retraction of growth cone filopodia following focal inactivation of calcineurin. Nature 376, 686-690.
6.  Yang, X. ‡, R. Khosravi-Far‡, H.Y. Chang‡, and D. Baltimore (1997) Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell 89, 1067-1076. ‡these authors contributed equally.
7.  Yang, X., H.Y. Chang, and D. Baltimore (1998) Autoproteolytic activation of pro-caspases by oligomerization. Molecular Cell 1, 319-325.
8.  Yang, X., H.Y. Chang, and D. Baltimore (1998) Essential role of CED-4 oligomerization in CED-3 activation and apoptosis. Science 281, 1355-1357.
9.  Chang, H.Y., H. Nishitoh, X. Yang, H. Ichijo, and D. Baltimore (1998) Activation of Apoptosis Signal-regulating Kinase 1 (ASK1) by the adapter protein Daxx. Science 281, 1860-1863.
10.  Chang, H.Y. (1998) Molecular studies of Fas signaling and programmed cell death. Massachusetts Institute of Technology, Doctoral Thesis.
11.  Chang, H.Y., X. Yang, D. Baltimore (1999) Dissecting Fas signaling with an altered specificity death-domain mutant: Requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation. Proc. Natl. Acad. Sci. USA 96,1252-1256.
12.  Chang, H.Y. and X. Yang. (2000) Proteases for cell suicide: regulation and functions of caspases. Microbiol. Molec. Biol. Review 64, 821-846.
13.  Chang, H.Y., J.-T. Chi, S. Dudoit, C. Bondre, M.v.d. Rijn, D. Botstein, P. O. Brown. (2002) Diversity, topographic differentiation, and positional memory in human fibroblasts. Proc. Natl Acad. Sci. USA 99, 12877-12882. http://genome-www.stanford.edu/fibroblast/
14.  Chi, J-T. ‡, H.Y. Chang‡, N.N. Wang, D.S. Chang, N. Dunphy, P.O. Brown (2003) Genome-wide view of gene silencing by small interfering RNAs. Proc. Natl Acad. Sci. USA 100, 6343-6346. ‡these authors contributed equally. Recommended by Faculty of 1000.
15.  Chi, J.T., H.Y. Chang, G. Haraldsen, O. Troyanskaya, D.S. Chang, S.G. Rockson, D. Botstein, P.O. Brown (2003) Endothelial cell diversity revealed by global gene expression profiling. Proc. Natl Acad. Sci. USA, 100, 10623-10628. http://microarray-pubs.stanford.edu/endothelial/
16.  Chang, H.Y., K. Wong, M. Bosenberg, P.H. McKee, H.A. Haynes. (2003) Myelogenous leukemia cutis resembling stasis dermatitis. J. Amer. Acad. Dermatology, 49, 128-129.
17.  Chang, H.Y. , T. W. Ridky, A. B. Kimball, E. Hughes, and A. E. Oro. (2003) Eruptive xanthomas and olanzapine use. Archives of Dermatology,139,, 1045-1048.
18.  Chang, H.Y., Z. Cooper, S. M. Swetter, M. P. Marinkovich. (2004) Kinetics and specificity of Fas ligand induction in toxic epidermal necrolysis. Archives of Dermatology,140, 242-244.
19.  Chang, H.Y. (2004) Young Investigator Award 2003: Topographic differentiation of fibroblasts. J. Amer. Acad. Dermatology, e1.
20.  Chang, H.Y., J.A. Thomson, Chen, X. (2004) Microarray analysis of stem cells and differentiation. In: Handbook of Adult and Fetal Stem Cells. R. Lanza et al., Eds. (San Diego: Academic Press).
21.  Chang, H.Y., J.B. Sneddon, A. Alizadeh, R. Sood, R. West, J.T. Chi, M.v.d. Rijn, D. Botstein, P.O. Brown (2004) Gene expression signature of fibroblast serum response predicts human cancer progression: Similarities between tumors and wounds. PLoS Biology, 2, 206-214. http://microarray-pubs.stanford.edu/wound/. Featured on National Public Radio "Science Friday". BBC News, Genome News Network, Lancet Oncology and Genome Biology.
22.  Chang, H.Y., D.S.A. Nuyten, J.B. Sneddon, T. Hastie, R. Tibshirani, T. Sorlie, H. Dai, Y. He, L.v.t. Veer, H. Bartelink, M.v.d. Rijn, P.O. Brown, M.J.v.d. Vijver. (2005) Robustness, scalability, and integration of a wound response gene expression signature in predicting breast cancer survival. Proc. Natl Acad. Sci. USA,102, 3738-3743.
Cover article. Editorial in PNAS 102, 3531-2. Featured in JAMA, Nature Review Cancer, Science News.
23.  Chang, H.Y., Wang, N., Chi, J.-T. (2005) High throughput RNA interference. In: RNA interference Technology: From Basic Science to Drug Development. K. Appasani, Ed. (Cambridge, UK: Cambridge University Press).
24.  Chang, H.Y. (2005) Programmed cell death in cancer pathogenesis and treatment. In: Cancer Chemotherapy and Chemoprevention, J. Han, ed. (Beijing, PRC: Scientific Publisher).
25.  Chang, H.Y., J.A. Thomson, Chen, X. (2005) Microarray analysis of stem cells and differentiation. In: Essentials of Stem Cell Biology. R. Lanza et al., Eds. (San Diego: Academic Press).
26.  Tang, J., H.Y. Chang, X. Yang. (2005) The death domain associated protein modulates activity of the transcriptional cofactor Skip/NcoA62. FEBS Letters. 579, 2883-90.
27.  Wong, D.J.., H.Y. Chang (2005) Learning more from microarrays: Insights from modules and networks. J. Investigative Dermatology, 125, 175-182.
28.  Adler, A.S., M. Lin, H. Horlings, D.S.A. Nuyten, MJ. vd Vijver, H.Y. Chang (2006) Genetic regulators of large-scale transcriptional signatures in cancer. Nature Genetics, 38, 421-430.
Featured in Nat Review Genet, 2006, 7, 244-245; Cancer Cell 2006, 9, 245-347; Nat Biotech 2006, 24, 524-6.
29.  Adler, A.S., H.Y. Chang (2006)From description to causality: Mechanisms of gene expression signatures in cancer. Cell Cycle, 5, 1148-1151.
30.  Ray, S., K.R. Atkuri, D. Deb-Basu, A.S. Adler, H.Y. Chang L.A. Herzenberg and D.W. Felsher (2006) MYC overexpression can induce DNA breaks in vivo and in vitro through mechanisms independent or dependent upon ROS production.Cancer Research, 66, 6598-6605.
31.  Rinn, J.L., C. Bondre, H. B. Gladstone, P.O. Brown, H.Y. Chang (2006) Anatomic demarcation by positional variation in fibroblast gene expression programs.PLoS Genetics, 2, e119.
Featured in New York Times, NY Daily News, Genome News Network, American Scientist.
32.   Sneddon, J.B., H.H. Zhen, K. Montgomery, M. vd Rijn, A.D.Tward, R. West, H. Gladstone, H.Y. Chang, G.S. Morganroth, A.E. Oro, P.O. Brown (2006) BMP antagonist Gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation.Proc. Natl Acad. Sci. USA,, 103, 14842-14847.
33.   Huang, W., H.Y. Chang, T. Fei, H. Wu, Y-G. Chen (2006) GSK3 mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene, in press.
34.   Chang, HY, J.A. Thomson, X. Chen.(2006) Microarray analysis of stem cells and differentiation. Methods in Enzymology, in press.
35.   Chang, HY, (2006) Patterning skin pigmentation via Dickkopf (Invited commentary). J. Investigative Dermatology, in press.
36.   Huang, W, Chang, HY, Fei, T, Wu, H, Chen, YG. (2006) GSK3beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene, Advance online publication, 9 October 2006; doi:10.1038/sj.onc.1210033.
37.   Nuyten DS, Kreike B, Hart AA, Chi JT, Sneddon JB, Wessels LF, Peterse H, Bartelink H, Brown PO, Chang HY, Van de Vijver MJ. (2006) Predicting a local recurrence after breast-conserving therapy by gene expression profiling. Breast Cancer Res., 2006 Oct 30;8(5):R62
38.   Devoss J, Hou Y, Johannes K, Lu W, Liou GI, Rinn J, Chang H, Caspi R, Fong L, Anderson MS. (2006) Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J Exp Med., 2006 Nov 20;

1.  U.S. Patent 6159731 "Daxx, a novel Fas-binding protein that activates JNK and apoptosis."
  2.  U.S. Patent 6916917 "Chimeric pro-caspases and methods of using same."
  3.  U.S. Provisional Patent 60/452,449 "siRNA microarray and methods for using the same."
  4.  U.S. Provisional Patent 60/452,379 "Methods and compositions for selective RNAi mediated inhibition of gene expression in mammal cells."
  5.  U.S. Provisional Patent 11/332,547 “Gene expression signatures for prediction of human cancer progression.”

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